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Effect of oral activated charcoal on quinine elimination.
Author(s) -
Lockey D.,
Bateman DN
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb05340.x
Subject(s) - quinine , activated charcoal , charcoal , oral administration , medicine , pharmacology , activated carbon , chemistry , immunology , malaria , organic chemistry , adsorption
The effect of repeated dose oral activated charcoal on quinine elimination has been studied following a therapeutic (600 mg) dose of quinine bisulphate to seven normal volunteers. Activated charcoal lowered quinine half‐life from 8.23 +/‐ 0.57 s.d. h to 4.55 +/‐ 0.15 s.d. h (P less than 0.001) and increased its oral clearance by 56%. Activated charcoal may have a role in the management of quinine poisoning.