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Rate‐controlled rectal absorption enhancement of cefoxitin by co‐ administration of sodium salicylate or sodium octanoate in healthy volunteers.
Author(s) -
Hoogdalem EJ,
Wackwitz AT,
Boer AG,
Cohen AF,
Breimer DD
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb05337.x
Subject(s) - sodium salicylate , bioavailability , cefoxitin , bolus (digestion) , sodium , pharmacology , rectal administration , absorption rate , medicine , absorption (acoustics) , chemistry , chromatography , biology , materials science , organic chemistry , composite material , bacteria , genetics , staphylococcus aureus
1. The effects of sodium octanoate and sodium salicylate on the rectal absorption of cefoxitin were investigated in healthy volunteers. Drug solutions were given either as a bolus or as a zero‐order infusion. 2. On rectal infusion sodium octanoate and sodium salicylate both enhanced mean cefoxitin bioavailability (+/‐ s.d.) from 5.0 +/‐ 1.2% to 9.1 +/‐ 1.3% and 9.2 +/‐ 1.5%, respectively. After rectal bolus delivery octanoate increased the mean cefoxitin bioavailability from 7 +/‐ 3% to 17 +/‐ 3%, whereas bolus salicylate did not produce a statistically significant effect. All formulations were well tolerated by the volunteers. 3. It is concluded that both octanoate and salicylate are capable of enhancing rectal cefoxitin absorption in man; rate of delivery seems to be an important factor.