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Pharmacokinetics of felodipine in patients with impaired renal function.
Author(s) -
Edgar B.,
Regardh CG,
Attman PO,
Aurell M.,
Herlitz H.,
Johnsson G.
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb05336.x
Subject(s) - felodipine , pharmacokinetics , renal function , cmax , urine , impaired renal function , metabolite , medicine , excretion , renal physiology , active metabolite , endocrinology , pharmacology , blood pressure , oral administration , chemistry , urology
1. The pharmacokinetics of felodipine and its effects on blood pressure and heart rate were studied in eight male patients aged between 28 and 57 years with a glomerular filtration rate, GFR, between 8 and 68 ml min‐1, following single i.v. and oral administration. 2. Clearance, Cmax, AUC, Vss and V, of felodipine were unaffected by the renal disease. The metabolite excretion (14C‐labelled) was slower than in healthy subjects. Initial renal clearance of these metabolites correlated with individual GFR values. The total amount of the dose excreted in the urine was also decreased.