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Lisinopril population pharmacokinetics in elderly and renal disease patients with hypertension.
Author(s) -
Thomson AH,
Kelly JG,
Whiting B.
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb05335.x
Subject(s) - lisinopril , pharmacokinetics , medicine , nonmem , renal function , volume of distribution , population , urology , blood pressure , ace inhibitor , kidney disease , pharmacology , angiotensin converting enzyme , environmental health
1. The population pharmacokinetics of lisinopril were investigated using data collected from two multicentre trials of lisinopril in the treatment of hypertension in elderly patients (n = 40) and patients with renal disease (n = 20). 2. Lisinopril was started at doses of 2.5‐ 5 mg daily and increased at 2‐4 weekly intervals as required for control of blood pressure. Steady‐state concentration‐time profiles were measured after at least 2 weeks at a constant dose. 3. All concentration‐time data were analysed simultaneously using the program NONMEM and the influence of clinical factors on clearance/F and volume of distribution/F was tested. 4. Clearance was significantly influenced by creatinine concentration, age, weight and cardiac failure. No clinical features tested were found to influence volume of distribution. 5. The influence of renal function and cardiac failure on lisinopril clearance has been confirmed using a population pharmacokinetic analysis technique.