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The effect of oral cilazapril and prazosin on the constrictor effects of locally infused angiotensin I and noradrenaline in human dorsal hand veins.
Author(s) -
Belz GG,
Beermann C,
Schloos J,
Kleinbloesem CH
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb03550.x
Subject(s) - cilazapril , prazosin , angiotensin ii , medicine , endocrinology , renin–angiotensin system , angiotensin iii , norepinephrine , pharmacology , chemistry , angiotensin converting enzyme , angiotensin ii receptor type 1 , ace inhibitor , blood pressure , antagonist , receptor , dopamine
The effects of the ACE inhibitor cilazapril (5 mg p.o.) and the alpha 1‐ adrenoceptor blocker prazosin (2 mg p.o.) were investigated on the dose‐ response curves to angiotensin I and to noradrenaline, administered locally in the hand veins in six healthy male volunteers in doses not producing systemic effects. Both angiotensin I and noradrenaline produced a dose‐dependent constriction of the congested veins. The angiotensin I effects were completely abolished after the administration of cilazapril but not significantly altered after the administration of prazosin. The noradrenaline dose‐response curves were shifted to the right (dose ratio about 10) by prazosin, but not by cilazapril. The data suggest that angiotensin I, after having been converted to angiotensin II exerts direct venoconstrictor effects which under resting conditions are not mediated by noradrenaline release.