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Differential effect of continuous administration of beta‐adrenoceptor antagonists on antipyrine and phenytoin clearance.
Author(s) -
Perrild H,
Kayser L,
Poulsen HE,
Skovsted L,
Jorgensen B,
Hansen JM
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb03541.x
Subject(s) - atenolol , metoprolol , phenytoin , propranolol , placebo , acebutolol , medicine , pharmacokinetics , pharmacology , endocrinology , blood pressure , epilepsy , alternative medicine , pathology , psychiatry
1. Antipyrine (1000 mg orally) clearance was studied 3 days before treatment with either atenolol (50 mg twice daily), metoprolol (100 mg twice daily), propranolol (80 mg twice daily) or placebo, and at day 5 and 18 during treatment. Phenytoin (100 mg intravenously) clearance was measured on days 0, 7 and 21 during treatment. 2. Antipyrine clearance was decreased by about 20% after 5 days of treatment with either propranolol or atenolol and this decrease persisted after 18 days of treatment. Antipyrine clearance did not change during treatment with either metoprolol or placebo. Phenytoin clearance did not change during any of the treatments.