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Bioelectrical impedance modelling of gentamicin pharmacokinetic parameters.
Author(s) -
Zarowitz BJ,
Pilla AM,
Peterson EL
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb03528.x
Subject(s) - gentamicin , pharmacokinetics , bioelectrical impedance analysis , elimination rate constant , volume of distribution , medicine , distribution volume , antibiotics , pharmacology , chemistry , body mass index , biochemistry
1. Bioelectrical impedance analysis was used to develop descriptive models of gentamicin pharmacokinetic parameters in 30 adult in‐patients receiving therapy with gentamicin. 2. Serial blood samples obtained from each subject at steady state were analyzed and used to derive gentamicin pharmacokinetic parameters. 3. Multiple regression equations were developed for clearance, elimination rate constant and volume of distribution at steady state and were all statistically significant at P less than 0.05. 4. Clinical validation of this innovative technique is warranted before clinical use is recommended.