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Evaluation of the gastric absorption and emptying of drugs under various pH conditions using a simple intubation method: application to diclofenac.
Author(s) -
Vidon N,
Pfeiffer A,
Godbillon J,
Rongier M,
Gauron S,
Hirtz J,
Bernier JJ,
Dubois JP
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb03515.x
Subject(s) - gastric emptying , diclofenac sodium , diclofenac , chemistry , absorption (acoustics) , chromatography , dosage form , drug , pharmacokinetics , pharmacology , stomach , medicine , gastroenterology , materials science , composite material
Sodium diclofenac (50 mg) together with [14 C]‐PEG as a non‐absorbable marker were dissolved in 400 ml of water (A), phosphate buffer pH 7.5 (B) or a homogenized meal (C). Each of these was ingested in random order by six volunteers on 3 consecutive days. Some gastric absorption of the drug was established with C but the plasma drug concentration‐ time profiles mainly reflected the process of gastric emptying.