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The effects of cilazapril alone and in combination with frusemide in healthy subjects.
Author(s) -
Johnston GD,
Passmore AP
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb03487.x
Subject(s) - cilazapril , renal function , chemistry , excretion , endocrinology , pharmacology , furosemide , sodium , medicine , metabolite , renal physiology , aldosterone , ace inhibitor , angiotensin converting enzyme , blood pressure , organic chemistry
1. In a fourway double‐blind placebo controlled study, the effects of cilazapril, a new angiotensin converting enzyme inhibitor, on renal function and the responses to intravenous frusemide were studied in a group of twelve salt depleted male volunteers. 2. Cilazapril produced an increase in effective renal plasma flow and urinary output of prostaglandin E2 metabolite (PGE2‐M) but no effect on sodium, potassium or water excretion. 3. Pretreatment with cilazapril antagonised the effects of frusemide on glomerular filtration, PGE2‐M and sodium excretion.