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Effect of food on the absorption of vigabatrin.
Author(s) -
FriskHolmberg M,
Kerth P,
Meyer P
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb03457.x
Subject(s) - vigabatrin , bioavailability , kinetics , pharmacokinetics , absorption (acoustics) , half life , chemistry , pharmacology , medicine , endocrinology , anticonvulsant , epilepsy , materials science , psychiatry , physics , composite material , quantum mechanics
1. This study, involving eight healthy volunteers, revealed that food intake does not have a clinically significant effect on vigabatrin kinetics. 2. Kinetics of vigabatrin in the fasting state showed low inter‐individual variation. 3. The plasma concentration vs time profile followed a bi‐exponential decline with a terminal half‐life of 6.8 h and a relative bioavailability of 92% +/‐ 11%. 4. In the clinical setting, vigabatrin may be taken at times convenient for the patient.