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The effect of indomethacin and enalapril on the cutaneous response to bradykinin.
Author(s) -
McAlpine LG,
Thomson NC
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb03452.x
Subject(s) - bradykinin , enalapril , angiotensin converting enzyme , pharmacology , chemistry , endocrinology , medicine , long term potentiation , prostaglandin , receptor , blood pressure
The angiotensin converting enzyme inhibitors potentiate the wheal response to intradermal bradykinin. Both converting enzyme inhibitors and bradykinin stimulate prostaglandin synthesis and prostaglandins enhance the cutaneous response to bradykinin. We examined the possibility that the increased wheal response to intradermal bradykinin in the presence of enalapril was due to the effect of prostaglandins. Indomethacin did not inhibit the potentiation by enalapril of the wheal response to bradykinin.