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Deep inspiration increases the absorption of inhaled sodium cromoglycate.
Author(s) -
Richards R,
Fowler C,
Simpson SF,
Renwick AG,
Holgate ST
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb03450.x
Subject(s) - sodium cromoglycate , inhalation , cromolyn sodium , absorption (acoustics) , anesthesia , lung function , pharmacology , medicine , pulmonary function testing , sodium , chemistry , asthma , lung , organic chemistry , physics , acoustics
The plasma concentrations of sodium cromoglycate were measured for 4 h following a single dose of 20 mg given by inhalation to six normal volunteers. A series of forced expiratory manoeuvres was performed 2 h after the dose, which resulted in a rapid and marked increase in the plasma concentrations of the drug. A similar increase was found in three volunteers who undertook a single deep inspiration at 4 h. These data indicate that the absorption of cromoglycate from the airways can be affected by manoeuvres used to assess lung function.