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The renal and haemodynamic effects of a 10 h infusion of glutamyl‐L‐ dopa in normal man.
Author(s) -
MacDonald TM,
Jeffrey RF,
Lee MR
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb03444.x
Subject(s) - natriuresis , plasma renin activity , aldosterone , endocrinology , medicine , blood pressure , excretion , effective renal plasma flow , free water clearance , atrial natriuretic peptide , urine , placebo , renal blood flow , hemodynamics , mean arterial pressure , renal function , renin–angiotensin system , kallikrein , heart rate , chemistry , alternative medicine , pathology , biochemistry , enzyme
1. gamma‐L‐glutamyl‐L‐dopa (gludopa) and placebo were given by intravenous infusion to 12 healthy salt replete men for 10 h in a single‐blind randomised fashion. 2. Gludopa caused a cumulative natriuresis of 46.5 mmol compared with placebo with a biphasic pattern and this was associated with a small reduction in body weight. 3. A small fall in arterial blood pressure and rise in pulse rate was seen with gludopa. 4. Plasma renin activity, atrial natriuretic peptide and urine kallikrein excretion were unchanged by gludopa but a small fall in urine aldosterone excretion, urine flow rate and free water clearance occurred. 5. The renal effects of gludopa are modest and last for only a few hours after the start of infusion.