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Stereoselective metabolism of metoprolol in Caucasians and Nigerians‐ relationship to debrisoquine oxidation phenotype.
Author(s) -
Lennard MS,
Tucker GT,
Woods HF,
Silas JH,
Iyun AO
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb03424.x
Subject(s) - debrisoquine , nigerians , metoprolol , medicine , population , endocrinology , metabolism , cyp2d6 , environmental health , cytochrome p450 , political science , law
The relationship between debrisoquine oxidation phenotype and the stereoselective metabolism of metoprolol was investigated in populations of British Caucasians (n = 139) and Nigerian subjects (n = 117). The 0‐8 h urinary S/R‐metoprolol (S/R‐M) ratio was related to the ability to metabolise metoprolol and debrisoquine in both ethnic groups. The median S/R‐M ratio was significantly higher in Caucasians (1.27) than in Nigerians (1.10). In the Caucasian population poor metabolisers of debrisoquine had significantly lower S/R‐M ratio (median = 0.84) than extensive metabolisers (median = 1.28). Bimodality in the frequency distribution of the S/R‐M ratio was not apparent in either ethnic group.