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Lack of effect of atenolol on the pharmacokinetics of theophylline.
Author(s) -
Cerasa LA,
Bertino JS,
Ludwig EA,
Savliwala M.,
Middleton E.,
Slaughter RL
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb05323.x
Subject(s) - atenolol , theophylline , pharmacokinetics , aminophylline , volume of distribution , medicine , pharmacology , bronchodilator , anesthesia , asthma , blood pressure
The effects of 3 days of pretreatment with cardioselective doses of atenolol on theophylline pharmacokinetics were determined. Nine healthy nonsmoking male volunteers received 6 mg kg‐1 i.v. aminophylline under baseline conditions and after both 50 mg day‐1 and 100 mg day‐1 atenolol. Theophylline clearance, volume of distribution and half‐life were not influenced by atenolol pretreatment. These data indicate that cardioselective doses of atenolol do not alter the pharmacokinetics of theophylline.