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Venous responsiveness to atrial natriuretic factor in man.
Author(s) -
Ford GA,
Eichler HG,
Hoffman BB,
Blaschke TF
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb05322.x
Subject(s) - medicine , cardiology , vein , endocrinology , atrial natriuretic peptide , dorsum , anatomy
The venorelaxant effect of atrial natriuretic factor in man was studied using the dorsal hand vein technique. Infusion of met‐ANF to preconstricted veins at doses up to 240 ng min‐1 in 11 healthy male subjects caused only minimal venorelaxation. Atrial natriuretic factor is unlikely to have a significant venorelaxant effect at physiological doses in man.