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Human alpha‐calcitonin gene‐related peptide (CGRP) is a potent vasodilator in human mesenteric vasculature.
Author(s) -
Marshall I.,
AlKazwini SJ,
Holman JJ,
Craig RK
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb05306.x
Subject(s) - calcitonin gene related peptide , vasodilation , sodium nitroprusside , endocrinology , medicine , mesenteric arteries , calcitonin , vascular smooth muscle , vasoconstriction , alpha (finance) , chemistry , artery , pharmacology , neuropeptide , smooth muscle , nitric oxide , receptor , surgery , construct validity , patient satisfaction
1. The effect of human alpha‐calcitonin gene‐related peptide (CGRP) and sodium nitroprusside have been measured on human isolated mesenteric vasculature and on rings of human superior mesenteric artery and saphenous vein. 2. When noradrenaline (10(‐5) M) was used as the vasoconstrictor in preparations perfused with Krebs solution at constant flow, human alpha‐CGRP was 10 times more potent than sodium nitroprusside in evoking dose‐dependent falls in perfusion pressure. 3. Human alpha‐CGRP and sodium nitroprusside were about equipotent at relaxing rings of superior mesenteric artery contracted by noradrenaline (10(‐6) M). When the tone of saphenous vein rings was raised by noradrenaline (10(‐6) M), human alpha‐CGRP did not relax the vascular smooth muscle. 4. The results show that human alpha‐CGRP is a potent vasodilator in human arterial preparations and may act preferentially on arterioles rather than large arteries.