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Polymorphism of debrisoquine hydroxylation among Finns and Lapps.
Author(s) -
Arvela P.,
Kirjarinta M.,
Kirjarinta M.,
Karki N.,
Pelkonen O.
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb05301.x
Subject(s) - debrisoquine , confidence interval , polymorphism (computer science) , medicine , phenotype , hydroxylation , genetics , pharmacogenetics , genotype , biology , gene , biochemistry , enzyme
Debrisoquine hydroxylation polymorphism was studied in 155 Finns and 70 Lapps. The frequency of the poor metabolizer phenotype was 3.2% among Finns (95% confidence interval 0.4‐6.0%) and 8.6% among Lapps (95% confidence interval 2.0‐15.1%).