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Reversal of histamine‐induced bronchoconstriction by the H1‐receptor antagonist levocabastine: a potential model for efficacy in anaphylaxis.
Author(s) -
Ferner RE,
Ward C.,
Kelly C.,
Connolly M.,
Bateman DN,
Rawlins MD
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb05290.x
Subject(s) - bronchoconstriction , saline , medicine , histamine , anesthesia , antagonist , placebo , pharmacology , receptor , airway , pathology , alternative medicine
1. The rate of onset and magnitude of the effect of levocabastine, a potent H1‐receptor antagonist, in reversing histamine‐induced bronchoconstriction were determined in a double‐blind cross‐over trial against saline placebo. Histamine was administered by nebuliser so that forced expiratory volume in 1 second (FEV1) was reduced to 80‐75% of baseline FEV1 in 10 men with mildly or moderately responsive airways and the effects of intravenous injection of saline or saline + 200 micrograms levocabastine were studied. 2. The maximum rate of recovery of FEV1 was 7[2‐10]% min‐1 (median [range]) in the first 5 min after levocabastine injection, but only 4[1‐7]% min‐1 after saline alone (P less than 0.05). 3. The median area under the recovery curve of FEV1 from 0 to 30 min after injection was 405 [228‐498]% basal FEV1 X min after levocabastine and 301[98‐502]% basal FEV1 X min after saline alone (P less than 0.002). 4. FEV1 returned to 90% of baseline within 30 min in all subjects after levocabastine, but not after saline alone (P less than 0.002). 5. Histamine‐induced bronchoconstriction was relieved more quickly by levocabastine than saline alone. This model may have application to the study of drugs used in the treatment of anaphylaxis.