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Interaction of salicylate and corticosteroids in man.
Author(s) -
Day RO,
Harris G.,
Brown M.,
Graham GG,
Champion GD
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb05286.x
Subject(s) - prednisone , sodium salicylate , medicine , concomitant , oral dose , corticosteroid , pharmacology , oral administration , pharmacokinetics
Corticosteroids have been reported to decrease the plasma concentrations of salicylate when salicylates have been administered chronically at high doses. In the present study, two single, oral doses of sodium salicylate, 10 mg kg‐1 were administered to six adult subjects with a variety of inflammatory conditions both before and during treatment with daily oral doses of prednisone (12‐60 mg). Concomitant prednisone therapy did not increase the whole body clearance of single doses of salicylate in these subjects (0.0275 +/‐ 0.08 l kg‐1 h‐1 before prednisone; 0.0247 +/‐ 0.03 l kg‐1 h‐1 during prednisone therapy; P greater than 0.05). These results indicate that corticosteroids do not alter the clearance of single doses of salicylate in man.