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The effect of inhaled ouabain on bronchial reactivity to histamine in man.
Author(s) -
Knox AJ,
Tattersfield AE,
Britton J.R.
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb05264.x
Subject(s) - histamine , ouabain , placebo , crossover study , medicine , reactivity (psychology) , asthma , endocrinology , pharmacology , chemistry , anesthesia , pathology , sodium , alternative medicine , organic chemistry
To determine the role of Na/K ATPase in determining bronchial reactivity in man, we studied the effect of 1 mg inhaled ouabain on histamine reactivity in six normal and 10 asthmatic subjects in a placebo controlled, crossover study. sGaw was measured before and up to 2 h after drug, followed by a histamine challenge test to estimate the dose of histamine causing a 35% reduction in sGAW (PD35). sGAW values after ouabain and placebo did not differ significantly. Ouabain did not affect bronchial reactivity, geometric mean (95% CI) PD35 histamine values following ouabain and placebo were 8.98 (3.8‐21.2) and 7.75 (3.2‐ 18.7) mumol respectively in normal subjects and 0.46 (0.18‐1.21) and 0.69 (0.22‐2.13) in asthmatic subjects. We were thus unable to demonstrate a role for Na/K ATPase in determining bronchial reactivity to histamine in man.