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The effect of allopurinol on the steady‐state pharmacokinetics of indomethacin.
Author(s) -
Pullar T.,
Myall O.,
Haigh J.R.,
Lowe J.R.,
Dixon JS,
Bird HA
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb05263.x
Subject(s) - allopurinol , pharmacokinetics , urine , pharmacology , urinary system , medicine , oral administration , steady state (chemistry) , chemistry
The effect of 5 days treatment with allopurinol (300 mg) on the pharmacokinetics of indomethacin at steady‐state was investigated in eight patients. Allopurinol produced no significant effect on the indomethacin serum concentration‐time curve. Allopurinol did not alter significantly the amounts of indomethacin excreted in the urine within 8 h. However, the urinary ratio of N‐deschlorobenzoylindomethacin to indomethacin was reduced significantly by allopurinol administration (P less than 0.05).