Premium
Excretion of tiapamil in breast milk.
Author(s) -
Hartmann D,
Lunell NO,
Friedrich G,
Rane A
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb03385.x
Subject(s) - excretion , breast milk , lactation , zoology , breast feeding , medicine , endocrinology , pregnancy , biology , pediatrics , biochemistry , genetics
The excretion of tiapamil in breast milk was studied in six lactating mothers (3‐7 days post partum) following a single oral 600 mg dose of the drug. The milk/plasma ratio of tiapamil derived from the areas under the plasma and milk concentration‐time curves was 0.44 +/‐ 0.10 mean +/‐ s.d.). Assuming an intake of 350 ml of milk during a dosing interval of 12 h, the newborn would be exposed at the maximum to 0.053 mg tiapamil. This small amount does not represent a risk for the baby.