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Bradykinin induced wheal and flare is not mediated by histamine release or cyclooxygenase products.
Author(s) -
Crossman DC,
Fuller RW
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb03375.x
Subject(s) - bradykinin , histamine , cyclooxygenase , terfenadine , pharmacology , chemistry , endocrinology , medicine , biochemistry , enzyme , receptor
The wheal and flare response to intradermal bradykinin was studied in man. The possibility that histamine and cyclooxygenase products are involved in the response to bradykinin was examined. Terfenadine given by mouth significantly inhibited the cutaneous response to histamine but the effect of bradykinin was unaltered. Similarly the cutaneous response to bradykinin was unchanged by aspirin.