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Effects of the beta 2‐adrenoceptor antagonist ICI 118,551 on blood pressure in hypertensive patients known to respond to beta 1‐ adrenoceptor antagonists.
Author(s) -
Robb OJ,
Webster J,
Petrie JC,
Harry JD,
Young J
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb03326.x
Subject(s) - atenolol , propranolol , antagonist , beta (programming language) , blood pressure , antagonism , medicine , adrenergic beta antagonists , heart rate , pharmacology , metoprolol , beta adrenoceptor , endocrinology , adrenergic receptor , receptor , computer science , programming language
1. The selective beta 2‐adrenoceptor antagonist ICI 118,551, 50 mg orally given thrice daily, did not lower blood pressure in hypertensive patients known to respond to therapy with atenolol or propranolol. 2. This dosage regimen resulted in a small decrease in supine heart rate which might represent partial beta 1‐adrenoceptor antagonism by ICI 118,551. 3. The results suggest that beta 2‐selective antagonism does not play a role in the hypotensive action of beta‐adrenoceptor antagonists.