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Lisinopril and nifedipine: no acute interaction in normotensives.
Author(s) -
Lees KR,
Reid JL
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb03308.x
Subject(s) - lisinopril , nifedipine , pharmacology , pharmacokinetics , crossover study , blood pressure , plasma renin activity , pharmacokinetic interaction , medicine , pharmacodynamics , endocrinology , angiotensin converting enzyme , ace inhibitor , drug interaction , renin–angiotensin system , chemistry , placebo , alternative medicine , pathology , calcium
1. A double‐blind, four period crossover study was undertaken to test for an interaction between single oral doses of nifedipine retard (20 mg) and lisinopril (20 mg) in normal subjects. 2. Side effects with both drugs were mild and the incidence was additive. 3. Blood pressure (BP) was lowered by nifedipine for 4 h, by lisinopril for 48 h and the combination showed simply additive effects. Standing heart rate was higher after the combination than after single treatment. 4. Plasma angiotensin converting enzyme (ACE) and renin activity (PRA), aldosterone, noradrenaline and adrenaline levels showed no evidence of an interaction. 5. The pharmacokinetics of lisinopril were unaltered by nifedipine and vice versa. 6. There is no evidence of a pharmacokinetic or pharmacodynamic interaction between single oral doses of nifedipine and lisinopril.