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Absorption of 5‐aminosalicylic acid from colon and rectum.
Author(s) -
Bondesen S,
Schou JB,
Pedersen V,
Rafiolsadat Z,
Hansen SH,
Hvidberg EF
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb03301.x
Subject(s) - bisacodyl , aminosalicylic acid , laxative , rectum , gastroenterology , jejunum , absorption (acoustics) , medicine , cathartic , chemistry , colonoscopy , constipation , colorectal cancer , materials science , cancer , composite material
In order to clarify the characteristics of absorption of 5‐ aminosalicylic acid (5‐ASA) from the colon, a neutral solution was instilled into the right part of the colon and the rectum, respectively, in six volunteers. A laxative (bisacodyl) and liquid meals were given prior to each instillation. No significant difference could be demonstrated between the two parts of the large bowel, but the absorption was considerably restricted compared with previous results obtained from the jejunum. The results confirm in a direct manner earlier observations on 5‐ASA released from sulphasalazine.