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(+)‐sulpiride antagonises the renal effects of gamma‐L‐glutamyl‐L‐dopa in man.
Author(s) -
MacDonald TM,
Jeffrey RF,
Freestone S,
Lee MR
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb03292.x
Subject(s) - sulpiride , endocrinology , medicine , plasma renin activity , effective renal plasma flow , natriuresis , renal function , renal blood flow , excretion , prolactin , renal physiology , chemistry , renin–angiotensin system , dopamine , blood pressure , hormone , dopaminergic
1. gamma‐L‐glutamyl‐L‐dopa (gludopa) was given by intravenous infusion to six healthy salt‐replete men on two occasions, with and without pretreatment with (+)‐sulpiride. 2. Gludopa increased sodium excretion, glomerular filtration rate and effective renal plasma flow whilst decreasing plasma renin activity. 3. (+)‐sulpiride had no significant effect on baseline natriuresis, renal haemodynamics or plasma renin activity, but significantly attenuated the rise in sodium excretion, glomerular filtration rate and effective renal plasma flow produced by gludopa. 4. (+)‐sulpiride abolished the acute fall in plasma renin activity seen with gludopa. 5. (+)‐sulpiride raised serum prolactin concentration but did not affect the ris in urine dopamine excretion rate caused by gludopa. 6. Gludopa exerts its renal effects by stimulating specific dopamine receptors which are principally of the DA1 subtype.