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Psychotropic effects of repeated doses of enalapril, propranolol and atenolol in normal subjects.
Author(s) -
Frcka G,
Lader M
Publication year - 1988
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1988.tb03283.x
Subject(s) - atenolol , enalapril , propranolol , placebo , medicine , essential hypertension , anesthesia , latin square , endocrinology , blood pressure , angiotensin converting enzyme , chemistry , rumen , alternative medicine , food science , pathology , fermentation
1 Enalapril 20 mg, propranolol 160 mg, atenolol 50 mg and placebo each were given once a day for 8 days to 12 normal volunteers, using a Latin‐ square design and double‐blind procedures. A battery of tests was applied before, 2 and 4 h after the dose on day 1 and 8. 2 EEG effects were detected on day 8 with propranolol but not consistently after atenolol or enalapril. 3 Reaction‐time, symbol copying and memory were impaired with propranolol; only memory was marginally affected by atenolol. Enalapril impaired memory but improved tapping ability. 4 Subjectively, propranolol was associated with drowsiness, enalapril with calmness and perhaps contentedness. Ratings of headache were increased with enalapril. 5 It is concluded that the apparent beneficial subjective effects of enalapril in clinical practice are attributable partly to intrinsic central effects but mainly to the contrast with beta‐adrenoceptor blockers such as propranolol.