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Bioavailability of rectally administered carbamazepine mixture.
Author(s) -
Neuvonen PJ,
Tokola O
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03258.x
Subject(s) - bioavailability , carbamazepine , rectal administration , oral administration , medicine , pharmacology , absorption (acoustics) , pharmacokinetics , route of administration , anesthesia , epilepsy , physics , psychiatry , acoustics
The relative bioavailability of carbamazepine mixture was studied after oral and rectal administration to healthy subjects. The absorption was significantly slower after the rectal than after the oral route but the total bioavailability was similar provided the mixture was not defaecated within 2 h of administration. We conclude that carbamazepine can be administered rectally, e.g. to postoperative patients in doses corresponding with oral doses.