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Respiratory stimulant effects of adenosine in man after caffeine and enprofylline.
Author(s) -
Smits P,
Schouten J,
Thien T
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03251.x
Subject(s) - caffeine , adenosine , anesthesia , respiratory minute volume , placebo , respiration , tidal volume , respiratory system , ventilation (architecture) , respiratory rate , adenosine receptor , stimulant , medicine , heart rate , blood pressure , anatomy , receptor , mechanical engineering , alternative medicine , pathology , engineering , agonist
In a double‐blind and randomized study the respiratory stimulant effect of continuous intravenous adenosine infusion was studied after previous administration of caffeine, placebo and enprofylline in 10 healthy young volunteers. After placebo, adenosine induced an increase of minute ventilation (from 6.3 to 12.5 l min‐1), tidal volume (from 0.60 to 0.96 l), and breathing rate (from 11.0 to 14.8 min‐1). Venous pCO2 fell and pH rose after adenosine. Caffeine significantly reduced the adenosine‐induced changes of minute ventilation, tidal volume, venous pCO2 and pH, whereas no changes occurred after enprofylline. Our results suggest that adenosine stimulates respiration in man by binding with specific P1‐purinoceptors, which can be blocked by caffeine, but not by enprofylline.