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Theophylline and antipyrine disposition in smoking and non‐smoking epileptic subjects.
Author(s) -
Acheson DW,
Uden S,
Braganza JM,
Brown SW,
Houston JB
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03250.x
Subject(s) - theophylline , anticonvulsant , disposition , pharmacology , drug , medicine , tobacco smoke , smoke , epilepsy , chemistry , psychology , psychiatry , environmental health , social psychology , organic chemistry
Theophylline and antipyrine disposition has been compared in smoking epileptic patients, non‐smoking epileptic patients and non‐smoking healthy volunteers. Although clear differences in drug clearance and half‐life were evident as a result of anticonvulsant drug therapy, no effect of smoking was discernible. Thus, additive effects from induction of the hepatic microsomal monooxygenase system in man by anticonvulsant drugs and polycyclic aromatic hydrocarbons (in cigarette smoke) were not evident.