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Effects of silybin on histamine release from human basophil leucocytes.
Author(s) -
Miadonna A,
Tedeschi A,
Leggieri E,
Lorini M,
Froldi M,
Zanussi C
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03241.x
Subject(s) - histamine , basophil , calcium , chemistry , ionophore , pharmacology , in vivo , extracellular , secretion , basophil activation , flavonoid , inhibitory postsynaptic potential , immunoglobulin e , endocrinology , biochemistry , immunology , biology , microbiology and biotechnology , organic chemistry , antioxidant , antibody
1. Effects of a naturally occurring flavonoid, silybin, on histamine release from human basophils were examined, in order to assess the potential utility in the treatment of allergic disorders. 2. The f‐met peptide and anti‐IgE‐induced histamine release was significantly (P less than 0.05) inhibited in a concentration‐dependent fashion. Conversely, no significant (P greater than 0.05) effect on calcium ionophore A23187‐induced histamine secretion was documented. The inhibitory activity was significantly (P less than 0.05) reversed by elevating extracellular calcium concentrations. 3. The anti‐allergic properties of silybin can be reasonably ascribed to a membrane‐ stabilizing activity, possibly related to an interference in calcium influx. These results indicate that an in vivo evaluation of the anti‐ allergic activity of silybin would be worthwhile.