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Temelastine does not affect theophylline pharmacokinetics in normal subjects.
Author(s) -
Charles BG,
Schneider JJ,
Norris RL,
Ravenscroft PJ
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03229.x
Subject(s) - theophylline , pharmacokinetics , aminophylline , crossover study , pharmacology , elimination rate constant , placebo , medicine , oral administration , bronchodilator , distribution (mathematics) , volume of distribution , anesthesia , asthma , mathematics , mathematical analysis , alternative medicine , pathology
The pharmacokinetics of theophylline (i.v. aminophylline 250 mg) were studied in a balanced, double‐blind crossover following the administration of oral temelastine (100 mg) or placebo, twice daily for 7 days, to 10 normal volunteers. Comparison of volumes of distribution, elimination rate constants, elimination half‐lives and areas under the plasma concentration‐time curve indicated that temelastine had no significant effect on theophylline pharmacokinetics.