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Comparative effect of famotidine and cimetidine on the pharmacokinetics of theophylline in normal volunteers.
Author(s) -
Lin JH,
Chremos AN,
Chiou R,
Yeh KC,
Williams R
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03228.x
Subject(s) - cimetidine , theophylline , famotidine , pharmacokinetics , pharmacology , histamine h2 receptor , medicine , receptor , antagonist
The comparative effect of famotidine or cimetidine on theophylline disposition was determined in healthy volunteers. Cimetidine, but not famotidine, caused a reduction in the rate of elimination of theophylline. The mean total body clearance of theophylline was reduced from 57.6 ml min‐1 before cimetidine to 39.5 ml min‐1 during cimetidine; and the half‐life was prolonged from 8.7 h before cimetidine to 12 h during cimetidine. The volume of distribution and renal excretion of theophylline were not affected by either famotidine or cimetidine.