Premium
Comparison of ketanserin and slow‐release nifedipine added to the treatment of hypertensive patients uncontrolled by a thiazide diuretic plus beta‐adrenoceptor blocker.
Author(s) -
Waller PC,
Solomon SA,
Ramsay LE
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03217.x
Subject(s) - ketanserin , nifedipine , medicine , blood pressure , supine position , diuretic , anesthesia , atenolol , heart rate , cardiology , receptor , 5 ht receptor , serotonin , calcium
1. Ketanserin or slow‐release nifedipine were added to the treatment of 24 patients with hypertension uncontrolled by a thiazide diuretic plus beta‐adrenoceptor antagonist in an observer‐blind, randomised parallel‐ group study of 6 months duration. 2. At 6 months the mean falls in supine blood pressure were for ketanserin (mean daily dose 77 mg) 7/5 mm Hg and for nifedipine (mean daily dose 62 mg) 27/10 mm Hg. The difference between the treatments was significant for systolic blood pressure (P less than 0.02) and mean arterial pressure (P less than 0.05). Six nifedipine‐treated patients reached target blood pressure, compared with one patient with ketanserin (P less than 0.02). 3. One patient taking nifedipine, and none taking ketanserin withdrew because of side‐effects. The tolerability of the two drugs was broadly similar. 4. Ketanserin treatment was associated with significant changes in supine pulse rate (‐8 beats min‐1, P less than 0.05) and corrected QT interval (+27 ms, P less than 0.05). Nifedipine treatment had no effect on these variables. The change in pulse rate was significantly different between the groups. 5. In patients treated with a diuretic and beta‐adrenoceptor blocker who required additional treatment ketanserin was significantly inferior to nifedipine.