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Pharmacokinetics of cyclosporin: influence of rate of constant intravenous infusion in renal transplant patients.
Author(s) -
Gupta SK,
Legg B,
Solomon LR,
Johnson RW,
Rowland M
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03206.x
Subject(s) - pharmacokinetics , renal transplant , medicine , elimination rate constant , plasma clearance , renal function , cyclosporins , urology , metabolic clearance rate , intravenous infusions , clearance , pharmacology , anesthesia , kidney , transplantation , volume of distribution
1 The pharmacokinetics of cyclosporin were studied in 12 renal transplant patients. Five patients received a constant rate (7 mg kg‐1 day‐1) intravenous infusion over 72 h and the remainder received rates of 7, 4 and 10 mg kg‐1 day‐1, consecutively each for at least 24 h. 2 Plasma, separated at 37 degrees C, was analysed by h.p.l.c. 3 The data were best described by a biexponential model. 4 Following the 72 h infusion, a plateau was reached by 24 h and clearance was 0.60 l h‐1 kg‐ 1. 5 Clearance associated with the 10 mg kg‐1 day‐1 infusion rate (0.43 l h‐1 kg‐1) was estimated to be lower than that following the 4 and 7 mg kg‐1 day‐1 rates (0.52 and 0.54 l h‐1 kg‐1 respectively) but the difference is unlikely to be of clinical significance.