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Cimetidine increases serum mebendazole concentrations. Implications for treatment of hepatic hydatid cysts.
Author(s) -
Bekhti A,
Pirotte J
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03186.x
Subject(s) - mebendazole , cimetidine , ingestion , gastroenterology , medicine , echinococcosis , pharmacology , surgery , biology , ecology
In eight patients (five with peptic ulcer disease and three with hydatid cysts), the [14C]‐aminopyrine breath test (ABT) and maximum serum concentration of mebendazole following a dose of 1.5 g of mebendazole three times daily were determined before and after treatment with cimetidine (400 mg three times daily for 30 days). Serum mebendazole concentrations were measured in blood samples taken 2 h after each drug intake. Cimetidine lowered the 14CO2 specific activity (SA) at 1 h (P less than 0.01) and increased the maximum serum concentration of mebendazole (P less than 0.01). A significant correlation was found between SA at 1 h and the highest concentration of mebendazole before (r = −0.71, P less than 0.05) and after (r = − 0.82, P less than 0.05) cimetidine ingestion. Combined administration of cimetidine and mebendazole resulted in the complete resolution of previously unresponsive hydatid cysts.