Premium
Prolactin response to low dose sulpiride.
Author(s) -
McMurdo ME,
Howie PW,
Lewis M,
Marnie M,
McEwen J,
McNeilly AS
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03153.x
Subject(s) - sulpiride , prolactin , placebo , endocrinology , medicine , pharmacology , hormone , antagonist , receptor , alternative medicine , pathology
1 Prolactin levels in response to sulpiride were studied in healthy volunteers. 2 Oral doses of 1 mg‐50 mg sulpiride or placebo were given. 3 A 3 mg sulpiride dose produced similar levels to those achieved with both 10 mg and 50 mg. 4 Circadian effects were studied showing no significant differences in the prolactin response to sulpiride. 5 Acute or chronic responses showed an attenuation with chronic sulpiride treatment to 50% of the peak levels attained with acute treatment. 6 These results indicate that sulpiride retains its potent ability to produce prolactin release even at the low doses studied here.