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Ethanol and platelet intracellular free calcium concentrations.
Author(s) -
Lees KR,
Barr SM,
Butters L,
Rubin PC
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03147.x
Subject(s) - calcium , platelet , ethanol , chemistry , calcium in biology , endocrinology , medicine , blood pressure , intracellular , biochemistry
The effect of 0.8 g kg‐1 absolute ethanol orally on platelet intracellular free calcium was assessed in a random order study in 24 normotensive subjects with an isocaloric control. Platelet calcium was measured 90 min and 12 h after treatment by the Quin 2 method. The study had 90% power of detecting a 16.5% change. After 90 min, breath ethanol was 37 +/‐ 9 micrograms 100 ml‐1, blood pressure was unchanged and heart rate rose slightly. Platelet calcium was unchanged by ethanol after 90 min or 12 h.