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Calcitonin suppresses gastric emptying of a radiolabelled solid meal in humans.
Author(s) -
Jonderko G,
Golab T,
Jonderko K
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03144.x
Subject(s) - gastric emptying , calcitonin , meal , medicine , endocrinology , pharmacology , chemistry , gastroenterology , stomach
The effects on gastric emptying of calcitonin/i.v. 1.5 i.u. kg‐1 body mass bolus or 10 i.u. followed by infusion to overall 1.5 i.u. kg‐1 body mass dose vs placebo were studied in four healthy volunteers and in four patients with an active peptic ulcer. Gastric emptying of a radiolabelled solid meal was surveyed. Pronounced delay in gastric emptying was observed in all studied subjects, mean transit time MTT90 calcitonin 39.2 +/‐ 0.85 min vs placebo 32.8 +/‐ 1.31 min, P less than 0.001.