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Enprofylline disposition in the presence and absence of amoxycillin or erythromycin.
Author(s) -
Sitar DS,
Aoki FY,
Hoban DJ,
Hidinger KG,
Montgomery PR,
Mitenko PA
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03136.x
Subject(s) - erythromycin , disposition , theophylline , bronchodilator , pharmacology , ingestion , antibacterial agent , pharmacokinetics , antibiotics , medicine , chemistry , asthma , psychology , social psychology , biochemistry
1 The kinetic disposition of a novel xanthine bronchodilator, enprofylline, was determined in young healthy male volunteers in the presence and absence of amoxycillin or erythromycin. These data were compared to those derived from a similar study of theophylline disposition in the presence and absence of erythromycin. 2 Erythromycin inhibited theophylline disposition only in those subjects in whom the control kinetic study was done after antibiotic ingestion, but the effect was modest. Erythromycin had no effect on enprofylline disposition. 3 Amoxycillin reduced the renal clearance of enprofylline, but the change was not statistically significant.