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Effect of prostacyclin on the perfusion pressure and on the vasoconstrictor response of angiotensin II in the human isolated foetal placental circulation.
Author(s) -
Soares Moura R
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03113.x
Subject(s) - prostacyclin , perfusion , angiotensin ii , placental circulation , endocrinology , placenta , medicine , renin–angiotensin system , blood pressure , vasodilation , vascular resistance , biology , fetus , pregnancy , genetics
The effect of prostacyclin infusion on the perfusion pressure and on the vasoconstrictor response to three doses of angiotensin II was investigated in six full‐term human placentas. The placentas were perfused with a modified Krebs‐Henseleit solution and placenta perfusion pressure was recorded. Prostacyclin 5 × 10(‐8) M, infused through the foetal placental circulation, produced a significant decrease in placental vascular resistance. The vasodepressor effect of prostacyclin persisted throughout the perfusion period and promptly disappeared when the infusion was stopped. The pressor response of angiotensin II was significantly reduced by prostacyclin infusion. These data suggest an interaction between the vascular effects of prostacyclin and angiotensin II on the placental circulation that might be important in the control of foetal placental blood flow.