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The oral retention and antiplaque efficacy of triclosan in human volunteers.
Author(s) -
Gilbert RJ,
Williams PE
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03094.x
Subject(s) - triclosan , toothpaste , saliva , dental plaque , medicine , dentistry , chemistry , pharmacology , pathology
An antiplaque toothpaste containing 0.2% (w/w) triclosan significantly inhibited overnight plaque growth in 12 human volunteers. After use of a 1 g quantity of the toothpaste containing 0.2% (w/w) [3H]‐triclosan, 36.3 +/‐ 1.4% of the triclosan was retained. The mean concentration (+/‐ s.d.) achieved in saliva 5 min after toothpaste use was 8.16 +/‐ 2.50 micrograms g‐1. The saliva decay curve for triclosan was consistent with a two phase model with t1/2 values of 0.45 h and 2.42 h, respectively. Triclosan was present in bacterial plaque for at least 8 h after dosage and in the oral mucosa for at least 3 h.