Premium
Placental transfer of flunitrazepam following intramuscular administration during labour.
Author(s) -
Kanto J,
Erkkola R,
Kangas L,
Pitkanen Y
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03082.x
Subject(s) - flunitrazepam , administration (probate law) , medicine , intramuscular injection , pharmacology , anesthesia , political science , benzodiazepine , law , receptor
After a single intramuscular dose of flunitrazepam 0.015 mg kg‐1 (n = 14) in women 37 to 41 weeks pregnant, the concentrations in the umbilical artery and amniotic fluid were significantly lower than in maternal venous plasma. Although the difference between the maternal venous and umbilical venous plasma concentrations was not significant, the mean fetomaternal ratio was 0.7. The plasma protein binding of flunitrazepam was 80 +/‐ 4% in the mother and 79 +/‐ 5% in the umbilical circulation. Both mothers and midwives subjectively estimated intramuscular flunitrazepam as a valuable sedative‐anxiolytic agent during the first stage of labour.