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Evidence for polymorphic oxidation of sparteine in Japanese subjects.
Author(s) -
Ishizaki T,
Eichelbaum M,
Horai Y,
Hashimoto K,
Chiba K,
Dengler HJ
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03080.x
Subject(s) - sparteine , debrisoquine , confidence interval , pharmacogenetics , medicine , incidence (geometry) , pharmacology , endocrinology , biology , cyp2d6 , chemistry , metabolism , genotype , genetics , stereochemistry , mathematics , cytochrome p450 , gene , geometry
The metabolism of sparteine which exhibits a genetic polymorphism in Caucasians was studied in 84 unrelated Japanese subjects. In contrast to a recent study where debrisoquine was used as a probe and no poor metabolizers could be observed in Japanese involving 100 subjects, two subjects had a urinary metabolic ratio of sparteine greater than 20 and thus were poor metabolizers of sparteine. The incidence of poor metabolizer phenotype of sparteine oxidation of 2% seems to be lower in Japanese as compared with various Caucasian populations where 5 to 10% are poor metabolizers of sparteine. However, this is not conclusive, because the 95% confidence interval of the observed frequency, 0.6 to 8%, covers the range reported in the literature for Caucasians.