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Chromosomal assignment of human cytochrome P‐450 (debrisoquine/sparteine type) to chromosome 22.
Author(s) -
Eichelbaum M,
Baur MP,
Dengler HJ,
OsikowskaEvers BO,
Tieves G,
Zekorn C,
Rittner C
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03075.x
Subject(s) - sparteine , debrisoquine , genetics , chromosome , biology , cyp2d6 , gene , karyotype , cytochrome , genetic linkage , microbiology and biotechnology , chemistry , genotype , stereochemistry , biochemistry , enzyme
In order to determine on which chromosome the gene controlling human cytochrome P‐450 (debrisoquine/sparteine type) is located a linkage study of polymorphic sparteine oxidation (PSO) to various polymorphic markers was carried out. Positive information for linkage between PSO and the P1 blood group was obtained with a maximal LOD‐score of LOD = 3.35 for both male and female recombination fraction estimates of theta m = theta f = 0.0. The P1 blood group has been recently mapped to the long arm of chromosome 22. Thus it can be concluded that the gene controlling human cytochrome P‐450 (debrisoquine/sparteine) is situated on the long arm of chromosome 22 in close vicinity to P1.