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Effect of guanfacine on ambulatory blood pressure and its variability in elderly patients with essential hypertension.
Author(s) -
Dupont AG,
Vanderniepen P,
Six RO
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03068.x
Subject(s) - guanfacine , blood pressure , ambulatory blood pressure , medicine , ambulatory , essential hypertension , placebo , anesthesia , heart rate , diastole , cardiology , clonidine , alternative medicine , pathology
The effect of guanfacine (2 mg once daily) on ambulatory blood pressure was studied with the Remler M 2000 recorder in 16 elderly hypertensive patients during a randomized, double‐blind, placebo‐controlled, balanced, cross‐over study. Guanfacine significantly reduced heart rate and systolic and diastolic ambulatory blood pressure. The antihypertensive effect was maintained over the whole recording period. Systolic and diastolic blood pressure variability was not changed by guanfacine, neither when defined as standard deviation or variation coefficient of the mean, nor when defined as the range between the highest and lowest ambulatory blood pressure, suggesting that blood pressure variability is unrelated to sympathetic nervous system activity.