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Lack of effect of smoking on the metabolism and pharmacokinetics of quinidine in patients.
Author(s) -
Edwards DJ,
Axelson JE,
Visco JP,
vanEvery S,
Slaughter RL,
Lalka D
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03057.x
Subject(s) - quinidine , metabolite , pharmacokinetics , pharmacology , drug , medicine , metabolism , population , drug metabolism , oral administration , environmental health
The urinary metabolite profile of quinidine and the oral clearance of this drug were studied under steady state conditions in five smoking and nine non‐smoking patients. No significant differences were observed in the urinary recovery of unchanged quinidine, 3S‐3‐hydroxyquinidine, 2′‐oxoquinidinone or quinidine‐N‐oxide between smokers and non‐smokers. In addition, the plasma clearance of quinidine was not affected by the smoking status of subjects. These results suggest that cigarette smoke does not induce any of the main pathways for quinidine metabolism in a typical patient population and that the consideration of smoking status is of little utility in aiding in the selection of initial dosage regimens for this drug.