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Metabolism of azathioprine to 6‐thioguanine nucleotides in patients with pemphigus vulgaris.
Author(s) -
Lennard L,
Harrington CI,
Wood M,
Maddocks JL
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03034.x
Subject(s) - azathioprine , pemphigus vulgaris , metabolism , nucleotide , medicine , dermatology , chemistry , physiology , pharmacology , biochemistry , disease , gene
Azathioprine metabolism, to red cell 6‐thioguanine nucleotides (6TGN), was studied in four patients with pemphigus vulgaris. Throughout treatment blood samples were taken for red cell 6TGN assay and differential white cell counts. Metabolite steady‐state occurred in three patients in 2, 2 and 4 months respectively. In the fourth patient red cell 6TGN concentrations increased slowly over 3 years. There was a significant negative correlation between 6TGN concentrations and the white blood cell count (rs = −0.92, P less than 0.0005) in this patient.